Over the course of the Progressive Era, revised scientific accounts of the connections between dust, germs, and disease recast debates over public health. The American School of Home Economics and other institutions affiliated with the emerging subfield of household bacteriology regarded detecting and eliminating pathogens as necessary means to achieve safer homes and communities. Although several historians have attributed the rise of early twentieth-century technocracy and the decline of grassroots health activism to germ theory, household bacteriology complicates this standard narrative. (...) Educators like Sophronia Maria Elliott (1854–1942) rejected the command-and-control tactics of the “new” public health and instead instructed women how to culture microorganisms and to measure the risks of infection within their surrounding environments using kitchen experiments. Household bacteriologists aspired to train “sanitary citizens” with the right and the duty to test for germs with everyday equipment, to prevent disease with effective housekeeping, and to advocate for policies and infrastructure to keep society well. (shrink)

From the mid-nineteenth century to the Gilded Age, Catharine Beecher and other American social reformers combined natural theology and evangelism to instruct their audiences how to lead healthy, virtuous, and happy lives. Worried about the consequences of urbanization, industrialization, unstable sexual and gender roles, and immigration, these “Christian physiologists” provided prescriptive scientific advice for hygiene and personal conduct based on the traditional norms of white, middle-class, Protestant domesticity. According to Beecher and her counterparts, the biosocial reproduction of ideal American households (...) promised to reverse the degeneration of men and women across the country and to ensure the long-term vitality of their children. Using evidence from Beecher, Harriet Beecher Stowe, Charlotte Perkins Gilman, and other nineteenth-century writers, I investigate the methods and aims of Christian physiology along with its relationships to natural theology, Darwinian feminism, and other reform movements. I also analyze how Beecher and her successors employed concepts including the machine, the tissue, the cell, and the germ to justify their conclusions about the optimal structure and functions of American society. Overall, I demonstrate how these actors leveraged the body and the family as mechanisms to produce healthy parents, children, and communities for an ailing nation. (shrink)

This book makes trouble: it explores the reality that digital culture is largely an extension of an older coloniality of power of the global north. It suggests a line of inquiry for the social sciences to reflect on their own imperial role and develop a contemporary critical and pragmatic scope, shifting their gaze from problems to opportunities.

Natural selection of specific protobiomonomers during abiogenic development of the prototype genetic code is hindered by the diversity of structural, spatial, and rotational isomers that have identical elemental composition and molecular mass (M), but can vary significantly in their physicochemical characteristics, such as the melting temperature Tm, the Tm:M ratio, and the solubility in water, due to different positions of atoms in the molecule. These parameters differ between cis- and trans-isomers of dicarboxylic acids, spatial monosaccharide isomers, and structural isomers of (...) α-, β-, and γ-amino acids. The stable planar heterocyclic molecules of the major nucleobases comprise four (C, H, N, O) or three (C, H, N) elements and contain a single –C=C bond and two nitrogen atoms in each heterocycle involved in C–N and C=N bonds. They exist as isomeric resonance hybrids of single and double bonds and as a mixture of tautomer forms due to the presence of –C=O and/or –NH2 side groups. They are thermostable, insoluble in water, and exhibit solid-state stability, which is of central importance for DNA molecules as carriers of genetic information. In M–Tm diagrams, proteinogenic amino acids and the corresponding codons are distributed fairly regularly relative to the distinct clusters of purine and pyrimidine bases, reflecting the correspondence between codons and amino acids that was established in different periods of genetic code development. The body of data on the evolution of the genetic code system indicates that the elemental composition and molecular structure of protobiomonomers, and their M, Tm, photostability, and aqueous solubility determined their selection in the emergence of the standard genetic code. (shrink)

This is the second of two special issues, and the articles are grouped according to two themes: The previous, first issue featured articles that shared the theme Technologies and the Political, while this second issue is focused on the theme of Subjectivities. In this second, somewhat expanded, introduction, the “sky’s the limit.” This introduction canvasses various theoretical and conceptual-empricial perspectives that the articles of both issues touch on and further tries to open many doors through which readers are invited to (...) go on their own rather than give readymade answers. This introduction is written not only to give both an overview of some of the most important conceptual, methodological, and empirical contexts that the two special issues evoke but also to create invitations for many further conversations to be had from here on forward by beginning the interrogating and troubling of the intercourse between “science” and “science fiction”: beause all of this has happened before and will happen again. (shrink)

The purpose of the paper is to analyze the interrelations between the notions of one’s own and the foreign in later Heidegger’s philosophy. It is pointed out that later Heidegger contextualized the notion of the world by the notion of home and its derivatives “homelessness” and “homecoming” that are of great value in his philosophy. The scrutiny proceeds from the study of the peculiarities of Heidegger’s approach to the problem of being that is considered to be the knot of his (...) philosophy. It is noted that Heidegger, having deserted the traditional ontology already in his early works, continued, nevertheless, using its terms including “being” for a long time and thereby in a way obscured the peculiarities of his approach. Only later Heidegger tried to reject the traditional concept of being as infinitely continuing state in favor of the concept of Ereignis that is usually translated as “appropriating event” or “event of appropriation”. Thus, according to Heidegger, being gives us beings as a whole by appropriating sense to them and thereby turning them into the familiar and accessible environment for dwelling. Just the “givenness” of beings as a whole makes them familiar, one’s own. Accordingly, the “dwelling” means for Heidegger not only the security, but also the intelligibility of the environment, whereas the homelessness means the latter’s uncanny incomprehensibility. It is emphasized that Heidegger’s interpretation of homelessness is closely connected with a standard theoretical model explaining the emergence of the private and public realms. According to this model, just the extension of family as the initial one’s own resulted in the turning of household into city-state that, having been specified by the image of one super-family, added the elements of the foreign to the initial state of society. (shrink)

The article reviews the concepts of the multi-author book Society. National Strategy. War: Political and Strategic Lessons of the First World War. This collective research is notable for rich original scientific apparatus and methodological proficiency. Thus, the analysis of participating countries is conducted according to a single template, which includes: the state of pre-war society in all participating countries ; goals of engaging in war and expectations of the powerful and financial elites for the war ; assessment of how did (...) different strata of society find the war; the evolution of the morale of the people during the war; problems that arose during the war ; the evolution of women’s position in society during the war, the development of a broad segment of women-workers, the extension of emancipation as one of the positive results of the war; the outcome of the war for the country. Special attention is drawn to the pacifist nature of the ideology of the reviewed research, demonstration of deprivation and suffering of people in all countries. The book’s authors identify the main causes of the First World War: ambitions and inefficiency of the world’s elites, the lack of a coherent strategy. As the result, the USA, thanks to their strategy, received the maximum dividends with minimal participation. At the same time, it is noted that the context of research on the nature of war should be expanded to take into account the general competition of countries and civilizations. The authors comprehensively analyze the informational and propaganda activities of the participating countries and conclude that England’s activities in this field were the most effective. Based on the methodology of this collective research, the nature of a future world war, its potential participants and their goals can be considered. (shrink)

The article focuses on juxtaposing the stances of Franz Rosenzweig and Emmanuel Levinas on the notion of the Other based on the metaphysical principles of modernity so as to expose the prerequisites for their attitude to metaphysics in whole. The peculiarity of the proposed approach is the analysis of the notions of the Other in Rosenzweig and Levinas from the perspective of Jacques Derrida’s philosophy. The scrutiny proceeds from the assumption that the national philosophies, having been considered as the specific (...) response to the effects of the encounter of societies to be modernized with the spreading modernity, for that very reason attach great importance to the construal of the Other. It is emphasized that the similarities between the national schools of philosophy indicate correlating the particular with the general as the paradigm for the comprehension of the Other, whereas the Jewish philosophy has previously conceptualized that paradigm by way of the opposition of “Athens and Jerusalem”. In an effort to assess the capabilities of the above-mentioned paradigm the analysis of the relevant range of problems is set into the wider context and they are considered in connection with the transition from essentialism to anti-essentialism that characterizes already the late modernity. It is disclosed that Rosenzweig’s stance was still essentialist, while Levinas tried to abandon the essentialist understanding of the Other, albeit he did not complete the transition to anti-essentialism. Levinas’ break with metaphysics was brought to a close by Derrida whose anti-essentialist stance on identity and difference radically diverges from the thinking that adheres to the “metaphysics of presence”. In the issue, Derrida who does not formally belong to the Jewish philosophy could afford to summarize Rozenzweig’s and Levinas’ approaches to the problem of the Other, and in so doing he makes a contribution to both general and Jewish philosophy. (shrink)

A critique and provincialization of Western social science and Global Northern academia by the author of The Digital Coloniality of Power, exposing shared colonial and extractive rationalities and histories of research, higher education, digitalization and bioeconomy while proposing in the idea of BluesCollarship a sketch for an alternative culture of worlding and commoning knowledge work and for making care matter in research and higher education. In a discourse analysis and provincialization of research and higher education, a tradition of elitarian White (...) Collaredness in academia and in the social sciences in general is criticized and an alternative attitude towards the production, transfer and use of knowledge - BluesCollarship - is proposed. The latter is rooted in a different idea of what 'infrastructure' is and in practices of decoloniality. Noting the current political climate of propaganda and populism, the persistence of social inequalities as well as of racism and misogynism, it is proposed that how people give warrant for knowledge claims should be reviewed under different terms. A coherent theme is that there is a genealogical root for current neo-extractive and neo-colonial rationalities in the Athenian idea of oikos conflating family, household, and property. In taking a distinctly writerly approach - rather than giving ready-made answers - the book aims at permanently provoking readers at every turn to think further, as well as before-and-beyond what is written, but to do so in thinking together with Others. Thereby the book addresses scholars and students from across the social sciences who seek challenges to established ways of thinking in academia without simply replacing one canon for merely another. This book is for those who think of themselves as knowledge and cultural laborers in this age of precarization who seek to replace the university and cognitive capitalism with a pluriversity and an infrastructure build on knowledge and culture as fundamental value. (shrink)

In this article, I consider the historical stages of development of nanotechnology in Russia as well as the political framework for this. It is shown that early federal nanotechnology programs in Russia date back to the 1990s and that since the mid-2000s, nanotechnology has attracted the increasing attention of government. I characterize the formation of the political landscape and the basic institutions for the promotion of nanotechnology in relation to the adoption of the Russian Federation president’s initiative “Strategy of Nanoindustry (...) Development” in 2007. The evaluative part of the article deals with three aspects: (a) bibliometric to assess Russian research output in nanotechnology, (b) scientific cadre to assess the research capacity of Russia in the long term, and (c) economical to consider the early results and prospects of the domestic nanoindustry. To construct the scientometric indicators, I used the Science Citation Index Expanded and some internal databases. The texts of program documents and available reports served as the source of economic information. (shrink)

While much excitement has been generated surrounding evidence-based medicine, internal documents from the pharmaceutical industry suggest that the publicly available evidence base may not accurately represent the underlying data regarding its products. The industry and its associated medical communication firms state that publications in the medical literature primarily serve marketing interests. Suppression and spinning of negative data and ghostwriting have emerged as tools to help manage medical journal publications to best suit product sales, while disease mongering and market segmentation of (...) physicians are also used to efficiently maximize profits. We propose that while evidence-based medicine is a noble ideal, marketing-based medicine is the current reality. (shrink)

The purpose of the research is to analyze the context, the essence, and the philosophical implications of Franz Rosenzweig's reconsideration of the ban on idolatry as an implication of pure monotheism. As often as not idolatry is defined generally as the adoration of some images that, representing deity, are considered to be autonomous and hereupon become the objects of worship. The study confines itself to the analysis of the significance of the ban on idolatry in Rosenzweig's interpretation of the concept (...) of difference that underlies his theoretical model of the Other. The consideration proceeds on the general assumption that the encounter of tradition with modernity is the factor that determines the radical change in the philosophies of societies under modernization. In this context, the ancient ban on idolatry means the rejection and prohibition of whatever representation as intricate mediation that is, in turn, the hallmark of modernity. However, according to Rosenzweig, idolatry is not the usage of images as the representations of the reputedly unrepresentable God, but the fixation on one image which would mean the arbitrary limitation of God's infinite freedom to reveal himself visually. This implies that the reconsidered ban on idolatry does not require the absolute prohibition of representation, but the latter should be construed as temporal. Such an approach prevents the identification of the representation of entity with this entity itself, the sign with the thing, and therefore prohibits self-referentiality. Rosenzweig's stance determines also his understanding of familiarity, unfamiliarity, and difference in art and translation. Rosenzweig's emphasis on the shocking influence of the defamiliarizing difference as the feature of the work of art correlates with his interpretation of the translation that should make stable shared senses unfamiliar. Thus, the reconsidered ban on idolatry underlies Rosenzweig's conception of the reconciliation between Jewish tradition and modernity. (shrink)

This is the first of two special issues and the articles are grouped according to two themes: This first issue will feature articles that share a theme we call Technologies and the Political, while the second issue will feature the theme Subjectivities. However, we could equally consider them exercises in provincialization in the (counter)factual register in the first issue, and by affective historiography as conceptual-empirical labor(atory) in the second issue. What we have generally asked of all authors is to consider (...) that the relation between science and society is often heavily influenced by and identified in the intermediary figurations portrayed in the genre of science fiction. (shrink)

The authors try to show that even Wittgensteinian definition of concept is not always sufficient to analyze what really happens in science. As a result, in addition to “concept” we propose “conception” as a new promising tool for philosophy of science. We provide a brief historical analysis of this term and reveal two main interpretations of “conception” in philosophy and scientific disciplines. In accordance with the first view, conception appears as either a “twin” of the concept, or a pair entity (...) to the concept. According to the second view, conception is a kind of “strange concept” that exists among “normal” concepts. Since conception is understood differently in sciences and philosophical systems, it is not possible to give a generalized definition of conception. That is, it is impossible to formulate this definition, so to speak, inductively. Moreover, even if it was possible, such a definition would not necessarily have to be automatically accepted by philosophy of science. That is why the introduction of a concept of conception was carried out through the analysis of a global process associated with the return of metaphysics to science. We define conception as a semantic construction denoting the unknown (and, possibly, fundamentally unknowable) and ensuring the possibility of working with this unknown (unknowable). By virtue of the way conception was introduced (conception is not a “generalization” of the interpretations available in specific sciences) many conceptions that are considered as conception in specific sciences turn out to not to be conceptions within this definition. Thus, the article interprets conception as a new possible tool of philosophy of science, which is aimed at understanding how specific sciences develop. (shrink)

Burt's critique of using polygenic scores in social science conflates the “scientific costs” of sociogenomics with “sociopolitical and ethical” concerns. Furthermore, she paradoxically enlists recent advances in controlling for environmental confounding to argue such confounding is scientifically “intractable.” Disinterested social scientists should support ongoing efforts to improve this technology rather than obstructing progress and excusing genetically confounded research.

Recently, a three-dimensional construct model for complex experiential Selfhood has been proposed (Fingelkurts et al., 2016b,c). According to this model, three specific subnets (or modules) of the brain self-referential network (SRN) are responsible for the manifestation of three aspects/features of the subjective sense of Selfhood. Follow up multiple studies established a tight relation between alterations in the functional integrity of the triad of SRN modules and related to them three aspects/features of the sense of self; however, the causality of this (...) relation is yet to be shown. In this article we approached the question of causality by exploring functional integrity within the three SRN modules that are thought to underlie the three phenomenal components of Selfhood while these components were manipulated mentally by experienced meditators in a controlled and independent manner. Participants were requested, in a block-randomised manner, to mentally induce states representing either increased (up-regulation) or decreased (down-regulation) sense of (a) witnessing agency (“Self”), or (b) body representational-emotional agency (“Me”), or (c) reflective/narrative agency (“I”), while their brain activity was recorded by an electroencephalogram (EEG). This EEG-data was complemented by first-person phenomenological reports and standardised questionnaires which focused on subjective contents of three aspects of Selfhood. The results of the study strengthen the case for a direct causative relationship between three phenomenological aspects of Selfhood and related to them three modules of the brain SRN. Furthermore, the putative integrative model of the dynamic interrelations among three modules of the SRN has been proposed. (shrink)

Nancy Jecker’s essay Nothing to be Ashamed of: Sex Robots for Older Adults with Disabilities 1 presents a provocative application of the capabilities approach. Her ethical argument for providing access to sex robots for older adults with disabilities proceeds in five parts: 1. Older adults frequently suffer disabilities that impair sexual functioning. 2. The ability to function sexually is linked to central human capabilities, including: the ability to generate a personally meaningful life narrative; be physically, mentally and emotionally healthy; experience (...) bodily integrity; feel and express a range of human emotions; affiliate deeply with others; and reflect on and choose a plan for their life. 3. Society should take reasonable steps to support these human capabilities at a minimal threshold as part of a broader duty to respect human dignity. 4. Providing access to sex robots comprises part of reasonable efforts to support the six capabilities at a minimal threshold. 5. Therefore, society ought to make reasonable efforts to ensure access to sex robots for older adults with disabilities that impair sexual functioning. I am sympathetic to this line of reasoning, having proposed a series of legal reforms that would facilitate sexual expression among older adults with cognitive impairments as well.2 3 …. (shrink)

ABSTRACT In this article, I consider how Nietzsche's history of morality in On the Genealogy of Morality is relevant to his critique of morality. I argue that, on Nietzsche's view, morality's history is a guide to whether and where we should expect to find coherence in our current moral practice. It helps us “structure our interpretation” of morality. History is relevant to critique because it reveals that morality is unlikely to have the kind of coherence required by many of its (...) defenders. After defending this account of how Nietzsche's historical claims are relevant to his critique, I use the account to explain why Nietzsche's genealogy mixes fact and fiction. (shrink)

Regardless of the theory of vagueness we adhere to, we all agree that no facts, known or practically knowable, suffice to determine the location of precise boundaries for vague concepts. According to the epistemic theory of vagueness, this ignorance is entirely an epistemic matter—vague concepts have sharp boundaries but we can never know their exact locations. Opposed to epistemicism is a view—or family of views—I shall call indeterminism. The indeterminist agrees with the epistemicist that we lack knowledge of the locations (...) of sharp boundaries to vague concepts but holds that this ignorance has a somewhat more dramatic source—vague concepts have no sharp boundaries for us to have knowledge of. In recent years, the epistemic theory of vagueness has come to joint the various versions of indeterminism as a theory well-enough supported by argument to demand to be taken seriously. In this paper, I shall try to explain why I am unconvinced by the body of argument that has been marshalled in support of epistemicism; I shall try to explain why we should continue to endorse an indeterminist picture of vagueness. (shrink)

Regardless of the theory of vagueness we adhere to, we all agree that no facts, known or practically knowable, suffice to determine the location of precise boundaries for vague concepts. According to the epistemic theory of vagueness, this ignorance is entirely an epistemic matter—vague concepts have sharp boundaries but we can never know their exact locations. Opposed to epistemicism is a view—or family of views—I shall call indeterminism. The indeterminist agrees with the epistemicist that we lack knowledge of the locations (...) of sharp boundaries to vague concepts but holds that this ignorance has a somewhat more dramatic source—vague concepts have no sharp boundaries for us to have knowledge of. In recent years, the epistemic theory of vagueness has come to joint the various versions of indeterminism as a theory well-enough supported by argument to demand to be taken seriously. In this paper, I shall try to explain why I am unconvinced by the body of argument that has been marshalled in support of epistemicism; I shall try to explain why we should continue to endorse an indeterminist picture of vagueness. (shrink)

Immanuel Kant’s “Schema” and J. G. Fichte’s “Bild” are parallel figures of activity that serve as bridges. For both Kant and Fichte, it is not the image/schema taken as product that is primary, but the act of imaging. I show how Fichte leans on the Kantian argumentation of the schematism in order to attempt bridging the gulf critical philosophy leaves between theoretical and practical philosophy. My broader purpose is to indicate how two German Idealists emphasize activity as a way of (...) solving philosophical problems. (shrink)

In recent decades, historians of religions have turned to, and developed, entirely new methodologies for the study of religion and human consciousness. Foremost among these are a collection of approaches often termed the “cognitive science of religion” (CSR), typically drawing on cognitive science, neuroscience, linguistics, and contemporary metaphor theory. Although we are still “early” in this enterprise, I hope to show how a meaningful dialogue between religious studies and contemporary neuroscience and cognitive science can help us to better understand some (...) intriguing mystical texts and practices from a tradition of medieval South Asian Hinduism. Known collectively as the Vaiṣṇava Sahajiyās, these followers of transgressive and antinomian Tantric Yoga provide excellent examples for exploring the nature of religion, ritual, consciousness, embodiment, identity, gender, emotions and sexuality. This paper will show how the study of these rich materials from seventeenth through eighteenth century Bengal in northeastern South Asia can be enhanced using insights from the philosopher Shaun Gallagher and the neurologist Patrick McNamara. (shrink)

Das Ziel des Bandes besteht darin, einen Überblick über die Grundfragen, Kernthemen und Handlungsfelder der praktischen Wirtschaftsphilosophie zu geben. Zu diesem Zweck befasst sich Teil I einführend mit dem Verhältnis von Ökonomie und Ethik, der Verbindung zwischen Wirtschaft, Gesellschaft und Politik sowie dem Zusammenhang von Globalisierung, Transnationalisierung und Interkulturalität. Teil II setzt sich mit den Kernthemen der praktischen Wirtschaftsphilosophie auseinander. Es werden Begriffe und Themen vorgestellt, die sowohl für die ökonomische Wissenschaft als auch für die Realökonomie relevant sind. Hierzu zählen (...) systematische und normative Begriffe wie Präferenzen, Rationalität oder Regeln, Grundlagenthemen wie Freiheit, Verantwortung oder Gerechtigkeit und operative Themenfelder wie Handel, Markt, Kooperation oder Digitalisierung. Teil III beschäftigt sich abschließend aus wirtschaftsphilosophischer Perspektive mit zentralen Praxisfeldern der Ökonomie. Dazu gehören das Verhältnis von Unternehmens- und Konsumentenverantwortung, die Rolle von Stakeholder-Beziehungen, Shared Value-Ansätze, die Verbindung von Governance und Institutionen sowie alternative Wirtschaftsformen und die Wirtschaftspolitik. Das Handbuch Wirtschaftsphilosophie verbindet in interdisziplinärer Perspektive philosophische Grundlagenreflexion mit theoretischer und praktischer Erschließung des ökonomischen Handelns. Methodisch werden dabei wissenschaftstheoretische, normative, kulturbezogene und historische Aspekte miteinander verbunden. (shrink)

Recent publications on Alfred Schutz suggest the importance of his musical thought for understanding his general viewpoint on intersubjectivity. Developing this proposition further, my article focuses on one aspect of Schutz’s writings on music: his attempts to amalgamate the aesthetic oppositions of the Dionysian/Apollonian by Friedrich Nietzsche and inner duration/spatialized time by Henri Bergson. Despite the seeming distortion of the initial meaning of the Dionysian impulse, I suggest that Schutz’s employment remains faithful to the aesthetic and cognitive theory of early (...) Nietzsche. To substantiate this, I draw a link between Nietzsche’s early theory of aesthetic cognition and the neurophysiology of the mid-nineteenth century. Furthermore, the way Schutz applied the Dionysian/Apollonian opposition to the problem of musical communication made his musical thought prefigure some neuro-scientifically inspired discussions of the present-day, like the one on joint attention. Schutz tackled the key paradox: why the experience of music can be shared but not directly communicated. (shrink)

Modeling mechanisms is central to the biological sciences – for purposes of explanation, prediction, extrapolation, and manipulation. A closer look at the philosophical literature reveals that mechanisms are predominantly modeled in a purely qualitative way. That is, mechanistic models are conceived of as representing how certain entities and activities are spatially and temporally organized so that they bring about the behavior of the mechanism in question. Although this adequately characterizes how mechanisms are represented in biology textbooks, contemporary biological research practice (...) shows the need for quantitative, probabilistic models of mechanisms, too. In this paper we argue that the formal framework of causal graph theory is well-suited to provide us with models of biological mechanisms that incorporate quantitative and probabilistic information. On the ba-sis of an example from contemporary biological practice, namely feedback regulation of fatty acid biosynthesis in Brassica napus, we show that causal graph theoretical models can account for feedback as well as for the multi-level character of mechanisms. However, we do not claim that causal graph theoretical representations of mechanisms are advantageous in all respects and should replace common qualitative models. Rather, we endorse the more balanced view that causal graph theoretical models of mechanisms are useful for some purposes, while being insufficient for others. (shrink)

Few studies have examined how trait emotion dysregulation relates to momentary affective experiences and the emotion regulation strategies people use in daily life. In the current study, 112 c...

On November 14, 1990, David Gray’s twenty-two hour shooting spree ended when the New Zealand Anti-Terrorist Squad shot Gray dead. In this paper I argue that Christians should support the existence of state agencies like the ATS who are authorized to use lethal force. Alongside the duty we as Christians have to love our neighbors, live at peace with others and to not repay evil for evil, God has authorized the government to use force when necessary to uphold a just (...) peace within the geographical area over which it has jurisdiction. (shrink)

The distinction between actus humanus and actus hominis is the best-known distinction in Thomas Aquinas’ theory of action. A human action (actus humanus) is a special case of an act of a human being (actus hominis). Several acts of our intellect and will form a human action and thereby put it from the realm of pure natural happenings (genus naturae) into the moral realm (genus moris). The paper at hand shows the character and main parameters of Thomas Aquinas’ action theory, (...) especially in the Summa theologiae I-II, quaestiones 6-17. Moreover, it presents Thomas Aquinas’ central idea of what is the essence of a human action. The analysis especially makes use of the element of command (imperium) It shows that, according to Aquinas, acting consists in the intellectually comprehensible self-disclosure of a person and therefore builds the basis for the moral evaluation of human actions. (shrink)

My premise is that a transmasculine experience of embodiment haunts the subject of The Second Sex. In light of her early philosophical essay on Claude Bernard, Beauvoir's account of sex difference may be read as the biological experience of “error” that foils what biopolitics and early twentieth‐century knowledge in the life sciences wanted to make of her. I argue that from this perspective the crucial discussion of the endocrine system of the human female in the Biology chapter adds a new (...) twist to the medical and scientific discourses for understanding transsexual identification. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

We announce two new dichotomy theorems for Borel equivalence relations, and present the results in context by giving an overview of related recent developments.§1. Introduction. For X a Polish space and E a Borel equivalence relation on X, a classification of X up to E-equivalence consists of finding a set of invariants I and a map c : X → I such that xEy ⇔ c = c. To be of any value we would expect I and c to be (...) “explicit” or “definable”. The theory of Borel equivalence relations investigates the nature of possible invariants and provides a hierarchy of notions of classification.The following partial ordering is fundamental in organizing this study. Given equivalence relations E and F on X and Y, resp., we say that E can be Borel reduced to F, in symbolsif there is a Borel map f : X → Y with xEy ⇔ fFf. Then if is an embedding of X/E into Y/F, which is “Borel”.Intuitively, E ≤BF might be interpreted in any one of the following ways: The classi.cation problem for E is simpler than that of F: any invariants for F work as well for E. One can classify E by using as invariants F-equivalence classes. The quotient space X/E has “Borel cardinality” less than or equal to that of Y/F, in the sense that there is a “Borel” embedding of X/E into Y/F. (shrink)